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Cancer Cure By Injectible Magnets

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British Scientists believe they’ve Made Major Cancer Breakthrough with Injectible Magnets That Target Cancer Cells Only .  London scientists today signalled a major breakthrough in cancer treatment. Patients could soon be treated by tiny magnets injected into the body and activated by remote control.  The robotic particles will target diseased cells and destroy them using heat, leaving healthy cells unharmed. [Full Article ...]


Nanoscale magnets in the form of iron-containing molecules might be used to improve the contrast between healthy and diseased tissue in magnetic resonance imaging (MRI)?as long as the concentration of nanomagnets is carefully managed?according to a new report* by researchers at the National Institute of Standards and Technology (NIST) and collaborators. Molecular nanomagnets are a new class of MRI contrast agents that may offer significant advantages, such as versatility in design, over the compounds used today. 4

Contrast agents are used to highlight different tissues in the body or to help distinguish between healthy and diseased tissue. NIST is working with two universities and a hospital to design, produce and test nanomolecules that might make MRI imaging more powerful and easier to perform. The new paper resolves a debate in the literature by showing that iron-containing magnets just two nanometers wide, dissolved in water, do provide reasonable contrast in non-clinical MRI images?as long as the nanomagnet concentration is below a certain threshold. A nanometer is one billionth of a meter.) Previous studies by other research groups had reached conflicting conclusions on the utility of molecular nanomagnets for MRI, but without accounting for concentration. NIST scientists, making novel magnetic measurements, were able to monitor the molecules’ decomposition and magnetic properties as the composition was varied. 4

Contrast agents are used to highlight different tissues in the body or to help distinguish between healthy and diseased tissue. NIST is working with two universities and a hospital to design, produce and test nanomolecules that might make MRI imaging more powerful and easier to perform. The new paper resolves a debate in the literature by showing that iron-containing magnets just two nanometers wide, dissolved in water, do provide reasonable contrast in non-clinical MRI images–as long as the nanomagnet concentration is below a certain threshold. A nanometer is one billionth of a meter.) Previous studies by other research groups had reached conflicting conclusions on the utility of molecular nanomagnets for MRI, but without accounting for concentration. NIST scientists, making novel magnetic measurements, were able to monitor the molecules’ decomposition and magnetic properties as the composition was varied. 5

Nanoscale magnets in the form of iron-containing molecules might be used to improve the contrast between healthy and diseased tissue in magnetic resonance imaging (MRI) ? Molecular nanomagnets are a new class of MRI contrast agents that may offer significant advantages, such as versatility in design, over the compounds used today. 7

Previous studies by other research groups had reached conflicting conclusions on the utility of molecular nanomagnets for MRI, but without accounting for concentration. NIST scientists, making novel magnetic measurements, were able to monitor the molecules’ decomposition and magnetic properties as the composition was varied. 38

The injectable dyes currently used as MRI contrast agents are of two types. Magnetic ions, which alter the nuclear properties of hydrogen in water, offer the advantage of consistent identical design but provide low contrast. The second category encompasses particles of thousands of atoms or crystals, which alter local magnetic fields; they provide contrast variation in a larger region but have irregular designs and magnetic properties that are difficult to control. By comparison, molecular nanomagnets can be designed to have consistent properties and high contrast. 38

Contrast agents are used to highlight different tissues in the body or to help distinguish between healthy and diseased tissue. NIST is working with two universities and a hospital to design, produce and test nanomolecules that might make MRI imaging more powerful and easier to perform. The new paper resolves a debate in the literature by showing that iron-containing magnets just two nanometers wide, dissolved in water, do provide reasonable contrast in non-clinical MRI images?as long as the nanomagnet concentration is below a certain threshold. A nanometer is one billionth of a meter.) Previous studies by other research groups had reached conflicting conclusions on the utility of molecular nanomagnets for MRI, but without accounting for concentration. NIST scientists, making novel magnetic measurements, were able to monitor the molecules? 7

The injectable dyes currently used as MRI contrast agents are of two types. Magnetic ions, which alter the nuclear properties of hydrogen in water, offer the advantage of consistent identical design but provide low contrast. The second category encompasses particles of thousands of atoms or crystals, which alter local magnetic fields; they provide contrast variation in a larger region but have irregular designs and magnetic properties that are difficult to control. By comparison, molecular nanomagnets can be designed to have consistent properties and high contrast. In addition, they might be modified to act as ?smart? Toxicity is not believed to be an issue, because iron is naturally found in the body and other studies have found that these materials are non-toxic at the concentrations used in MRI. 7

NIST works with Florida State University to make single-molecule magnets less than five nanometers (nm) in diameter, and works with the University of Colorado at Boulder to make nanocrystals in the 10-50 nm range. The agency is pioneering methods for manipulating and measuring the magnetic properties of these compounds and is developing instrumentation for understanding how contrast agents work and how to control contrast properties. Researchers correlate the measured properties to the observed MRI response under non-clinical conditions using imagers at The Children?s Hospital in Denver. The information gained is fed back into recipes for making even better nanomagnets. The work described in the new paper was supported in part by the National Science Foundation. 7

To understand this better, imagine a patient undergoing a routine breast cancer scan. Due to the leaky blood vessels in the tumor, SPIO particles confront the cancer cells and then bind to the breast cancer cells by the �lock and key mechanism�. The MRI scanner will produce an excellent contrast image which will help to visualize the presence and location of the tumor. 43

This invention relates to the preparation of novel coated inorganic particles and the use thereof. The coated inorganic particles of the present invention have particular utility for use as contrast agents in connection with the imaging of discrete areas of the body and will be described in connection with such utility, although other utilities are contemplated. 14

What does this have to do with oral drugs? Drugs that are consumed orally undergo an initial pass through the liver. Injectable preparations do not pass through the liver in the same way, and therefore they do not have the same degree of risk for clotting. 25

HylaForm is a material created from natural body substances. There’s no risk of infection, but you will need repeated treatments to maintain the result as it’s only a temporary fix. 6

Effective, safe reticuloendothelial system (RES) MRI contrast agent which can increase the sensitivity and differentiation of normal and pathologic tissue in the liver or spleen have been proposed in the art. However, existing modalities for other imaging procedures for the liver and spleen have approximately a 10-20% false-negative rate for detecting hepatic metastases, and a 40-50% false-negative rate for detecting lymphomatous involvement, necessitating laproscopic staging. Further, as pointed out above, tumor involvement of liver, spleen and other tissues has consistently been shown to increase T1 and T2 relaxation parameters to a variable and unpredictable degree, which also results in a high incidence of false-negative. RES agents are useful because liver replaced by tumor does not possess RES cells and therefore does not take up the contrast agent. Non-RES agents more randomly distribute between normal and pathologic tissue. 14

Hepatic disease conditions resulting in abnormally high levels of iron in the liver have been shown to produce laterations of tissue relaxation times as observed by MRI. See, for example, Doyle et al., AM J. Roentgenol (1982) 138: 193-200; Stark et al, Radiology (1983) 148: 743-751; and Runge, et al., Am. J. Roentgenol (1983) 141: 943-948. Observed decreases in T1 have been attributed either to paramagnetic enhancement of longitudinal relaxation, or to alterations of hydrated tissue proteins. Heretofore, the production of T2 diminution as seen in these disease states has not been produced with a potent, safe contrast agent. Soluble iron compounds have been tested as MRI contrast agents. Wesbey, et al Radiology (1983) 149: 175-180. 14

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